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Indications

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone. Read more

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Getting started with ENBREL

NEW TO ENBREL?

Here are some helpful things
to know as you get started

Hypothetical patient learning more about ENBREL®

  • Injecting ENBREL

    HOW TO INJECT ENBREL

    You have several options for taking ENBREL. You and your doctor will decide which one is right for you.

    Remember, the following information is intended to provide you with an overview and basic information about each injection device for ENBREL. They do not replace the Instructions for Use. That’s why it is extremely important that you thoroughly review the Instructions for Use for any device that you plan to use. Those instructions cover everything you need to know about how to use ENBREL.

    As always, please contact your healthcare provider if you have any questions.

    • AutoTouch® Autoinjectors

      AutoTouch® autoinjectors

      How it Works

      Indication

      Enbrel® (etanercept) is indicated for the treatment for patients with moderately to severely active rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, moderate to severe plaque psoriasis in adults and children 4 years and older, and moderately to severely active polyarticular juvenile idiopathic arthritis.

      VO:

      Welcome to the Injection Demonstration Video for all AutoTouch® autoinjectors, including the ENBREL Mini® cartridge with AutoTouch® Autoinjector and with AutoTouch Connect® Autoinjector. The AutoTouch® autoinjector and the AutoTouch Connect® autoinjector are the same autoinjector device and use the same ENBREL Mini® cartridges. Additionally, both autoinjectors follow the same injection steps. The only difference is that the AutoTouch Connect® features BLUETOOTH® technology. The Bluetooth® technology in the AutoTouch Connect® Autoinjector allows you to automatically track your injections in the Embark® App. The Bluetooth® word mark and logos are registered trademarks owned by Bluetooth SIG, Inc. and any use of such marks by Amgen is under Iicense. After watching the full injection demonstration video, please visit Enbrel.com/Embark to learn more about the Embark® App. Prescription ENBREL® (etanercept) is taken or given by injection. The video you’re about to see is intended to provide you with an overview and basic information about all AutoTouch® autoinjectors. This video is not a comprehensive review of all AutoTouch® autoinjectors and does not replace the Instructions for Use. Please review with your healthcare provider the Patient Instructions for Use included with all AutoTouch® autoinjectors. Be sure to talk to your healthcare provider about any questions or concerns you may have about your AutoTouch® autoinjector. The Important Safety Information, including Boxed Warning for ENBREL®, will be discussed later in this video.

      The Important Safety Information, including Boxed Warning for ENBREL®, will be discussed later in this video.

      Before starting ENBREL®, tell your doctor if you think you have an infection, or if you have a fever, cough, flu-like symptoms, or an open sore.

      You should not start taking ENBREL® if you have any kind of infection unless your healthcare provider says it is okay.

      You should not use or inject yourself unless your healthcare provider has shown you how. It is important that you read and understand the Instructions for Use that are also included with your ENBREL medication packaging. If someone else is giving you the injection, he or she should also be trained with the Instructions for Use first.

      Remember, if at any time you're unsure how to use ENBREL Mini® with AutoTouch®, contact your doctor or call 1-888-4ENBREL.

      TALENT 1: Hi there, in this video we're going to provide you with some helpful information about ENBREL Mini® with AutoTouch® and highlight some of its features. I'll also show a demonstration of how I inject myself.

      TALENT 4: My doctor prescribed ENBREL for me, and my nurse showed me how to inject.

      TALENT 2: My doctor's nurse also told me that it's very important that before I inject myself for the first time, I read and understand the Instructions for Use, or IFU for short, included with my medication. Spending the time to read through these instructions before injecting, especially for the first time is very important, as it may reduce errors or mistakes.

      TALENT 3: To have the best injection experience, I first make sure I become familiar with the AutoTouch® features, then I follow these four steps: prepare, get ready, inject, and finish. Now, each of these steps is clearly laid out in the IFU.

      TALENT 1: There’s also a troubleshooting section if I need information on what to do if something goes wrong.

      TALENT 4: ENBREL Mini® with AutoTouch® is a reusable autoinjector, and it includes two parts: AutoTouch®, which is the reusable autoinjector, and ENBREL Mini®, a small, disposable, single-dose, prefilled cartridge that contains medication.

      TALENT 3: ENBREL Mini® with AutoTouch® was designed with patients in mind, with a comfortable gray finger grip and an easy-to-press status button on top. I push the status button when I'm ready to give myself an injection.

      TALENT 1: Another nice feature about the AutoTouch® is that the design makes it so the needle is not seen throughout the injection process.

      TALENT 2: The progress bar on the AutoTouch® helps me keep track of the injection process. When the lights on this bar are gone, it indicates that the medication has been delivered.

      TALENT 3: A couple of other features are the sound switch and the injection speed switch, which let me choose what's best for me.

      TALENT 1: To turn the sounds off, I just slide the sound switch up to see the red bar, which lets me know that AutoTouch® is muted.

      TALENT 2: The speed switch lets me choose an injection speed that I find most comfortable. For a faster injection, I slide the switch up towards the plus sign. For a slower injection, I slide down towards the minus, and for something in between, I just leave the switch in the middle.

      TALENT 1: Okay. So now I'm going to demonstrate how I give myself an injection. To start the injection process, the first thing I need to do is take my ENBREL medication out of the fridge. I remove one Enbrel Mini® from the fridge and let it come to room temperature. The IFU recommends leaving it at room temperature for at least 30 minutes, so that's what I do. If the medication is still cold, it may be uncomfortable. Typically, I like to use this time to go for a walk.

      TALENT 5: Ready?

      TALENT 1: Yeah.

      TALENT 5: Let’s do it. Come on, Zoey. C'mon. Good girl.

      TALENT 4: After 30 minutes, I take my AutoTouch® out of a dry, safe place where I've stored it. Keep in mind that AutoTouch® shouldn't be stored in the fridge.

      TALENT 1: Then, I get all of my supplies ready and wash my hands thoroughly as described in the IFU.

      TALENT 1: I choose an injection site and clean it as mentioned in the IFU. Today, I'm going to use my thigh.

      TALENT 2: I can also choose my abdominal area, or if someone is giving me the injection, the outer area of my upper arm. Check the IFU if you're not sure where to inject.

      TALENT 3: I'm almost ready to inject. I press the door button to open the door to the AutoTouch®, and then slide in ENBREL Mini®. Remember, label side out, purple cap down.

      TALENT 1: It's important to insert the ENBREL Mini® cartridge correctly. Otherwise, it won't slide in.

      TALENT 3: Once ENBREL Mini® is in, all I have to do is close the door.

      TALENT 4: I hold the AutoTouch® with my fingers wrapped around the gray finger grip. Then, I pull the purple protective cap straight down and off. I place the AutoTouch® on my skin and hold it there. There's no need to stretch or pinch my skin. The green status button and chime sound let me know that I'm ready.

      TALENT 1: I press and release the green status button.

      TALENT 4: I'm very careful not to lift the AutoTouch® off my skin until I know that the injection is complete. I can see the progress on the display facing me and the green status light continuing to flash. I keep holding AutoTouch® straight and steady.

      TALENT 1: I continue to hold AutoTouch® on my skin until the green light turns off and I hear a chime letting me know that my injection is now complete.

      TALENT 4: Then I lift the AutoTouch® off my skin, and the door will open automatically. I slide the empty ENBREL Mini® out and dispose of it in an FDA-cleared sharps disposal container.

      TALENT 2: Now, I clean the AutoTouch® and put it back in a safe, dry place. The AutoTouch® can be reused for multiple injections. It typically lasts for up to 2 years, or 130 cycles, from the first injection.

      TALENT 4: The ENBREL Mini® cartridges are not reusable. I use a new one every time I need to inject. I'm done. Another helpful hint, if at anytime during the injection process you hear an alarm sound, or the status button turns red, please go to the Instructions for Use.

      TALENT 2: If you need further assistance, please call your doctor or 1-888-4ENBREL.

      [ISI]

      TALENT 1: Remember these five things every time you inject: prepare and clean your injection site.

      TALENT 2: Hold the ENBREL Mini® single-use cartridge with labeled side facing out and slide into door. Remove purple cap.

      TALENT 4: Place and hold AutoTouch® on skin and wait for the status button to turn green.

      TALENT 3: To start an injection, press and release the green status button.

      TALENT 1: Injection is finished when you hear a chime and all the lights are turned off. Thanks for watching.

      COLLAPSE

      How to Pair with the Embark® App

      Indication

      Enbrel® (etanercept) is indicated for the treatment for patients with moderately to severely active rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, moderate to severe plaque psoriasis in adults and children 4 years and older, and moderately to severely active polyarticular juvenile idiopathic arthritis.

      VO:

      Welcome to the Embark® App Pairing Video Tutorial. Today, we’ll show you how to pair your new AutoTouch Connect Autoinjector with the Embark® App on your iPhone, Android, iPad mini, or iPad. The Embark® App automatically records each day that you take your medication. If you do not have the AutoTouch Connect autoinjector with Bluetooth® technology, you may still enter this information manually in the app. The steps for manual tracking will be described later in the video. And please remember that the AutoTouch Connect can only be paired with the Embark® App. Let’s get started; this will only take a couple minutes. First, please make sure your iPhone or Android phone has the Bluetooth® icon turned on. If you haven’t yet downloaded the free Embark® App, then please do so now from the App Store or Google Play. Once downloaded, the Embark® App will walk you through the process of creating an account. Or if you already have an account, sign in with your username. After completing, you should see the “Embark® App Account Created!” notification. Now you can begin pairing. Select “Continue,” and make sure to allow notifications. If you don’t select “Allow,” the Embark® App will not be enabled to send you reminders. You are now on the home screen. Tap “Add your medicines,” select “Continue,” and then select ENBREL. A “Warning” prompt will appear to ensure you are about to enter the correct dosage as prescribed. Tap “OK.” Next, make sure it says ENBREL and then type in your dosage. Now you can tap how often you take ENBREL. And the time you usually take it so a reminder can be set for you automatically. Now it’ll ask you which device you’re using. Tap on “ENBREL Mini® cartridge with all AutoTouch® autoinjectors,” as this will also connect with your AutoTouch Connect autoinjector. Then press “Next.” Make sure you have your AutoTouch Connect nearby before pairing, and keep it within 10 feet of your phone or iPad for it to initiate the connection. The next screen will say “Pair Your Autoinjector.” If your device has the Bluetooth® symbol, select “Automatic Recording.” This allows the Embark® App to communicate with your AutoTouch Connect device and record your injections within the Embark® App. Next, you’ll be asked to “Use Bluetooth®,” so select “OK.” Your location services must be turned on. Please select “Allow While Using App” for the best user experience. Now, follow these three steps to connect. One: on your Autotouch Connect, press eject to open the door. Two: close the door without adding a cartridge. Three: on your phone, tap “Next” to start connecting. You will be prompted to type in the last 4 digits of your device’s serial number. You can find them on the back of your device here. Once you’ve entered them, tap “Next.” When asked, select “Pair” just like you would with a wireless speaker or headphones. You’ll see an “Almost there” message appear while it’s syncing. Then tap “Continue” to finish adding ENBREL and enable automatic recording, so the Embark® App can automatically record your injections. If you want, you can add a refill reminder. Or you can add one later if you don’t have that information available now. Just make sure you review all the information you’ve entered to make sure it’s correct, then tap “Done.” And that’s it! Your device is paired. A quick note: If you have an injection device that does not have Bluetooth®, you can still use the Embark® App to manually record your injection information. To do so, select “Manual Recording” on your phone. Here, you can still enter your injections manually so that you can track them with the Embark® App. As an additional feature, you can also view or email yourself customized medication reports, and if you like, print them out to share with your doctor. You can even ask the Embark® App to send you medication reminders. So be on the lookout! Now you’re all set to “Embark”! If you have any questions about the AutoTouch Connect®, call ENBREL Support® at 1-888-4ENBREL.

      COLLAPSE

      The AutoTouch® and the AutoTouch Connect® autoinjectors are very similar injection devices. Both help you track your injection from start to finish with light and sound cues. Both autoinjectors also follow the same injection steps. The only difference is that the AutoTouch Connect® autoinjector has Bluetooth® connectivity, which allows you to automatically sync your tracking info into the Embark App.

      For more information on the AutoTouch® autoinjectors

      Download The Guide
      COLLAPSE

    • SureClick® Autoinjector

      SURECLICK® AUTOINJECTOR

      The SureClick® autoinjector allows you to take your ENBREL with the press of a button. Plus it’s designed to make a clicking noise when you start and finish your injection.

      Please note: this device is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with JIA who weigh less than 138 pounds (63 kg).

      For more information on the SureClick® autoinjector

      Download The Guide
      COLLAPSE

      • READ VIDEO TRANSCRIPT

        How it Works

        Indication

        Enbrel® (etanercept) is indicated for the treatment for patients with moderately to severely active rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, moderate to severe plaque psoriasis in adults and children 4 years and older, and moderately to severely active polyarticular juvenile idiopathic arthritis.

        VO:

        MARY: Coming!

        LORIE: Mary?

        MARY: Hi!

        LORIE: Hi, I’m Lorie, your ENBREL Nurse Partner.

        MARY: Hi, Lorie. Come on in! Thanks for coming over.

        LORIE: Absolutely, my pleasure.

        LORIE: So, as you know, I’m here to help you as you get started with the SureClick Autoinjector.

        MARY: Great.

        LORIE: Think of today as a demonstration that can help supplement the training that you received in your physician’s office. So, I’ll go over things in detail. But before I do, your SureClick came with Instructions for Use.

        MARY: I have one, yup. I reviewed it with the nurse when we received training in the office and read it just before you came over. I’m really glad you are here, because this is the first time I’m injecting myself at home.

        LORIE: Oh, you’re welcome and that’s great. You should always read the instructions for use before injecting and also refer to it if you have any questions.

        MARY: Great.

        LORIE: Alright, so are you ready to get started?

        MARY: Ready.

        LORIE: Now, before you do the actual injection, I want to show you some features of the SureClick Autoinjector.

        LORIE: So, the first thing is understanding which end is which. So, see this purple button? That’s the top, and that’s the start button. Your thumb goes here. This white cap covers the needle. Do not remove the white cap until you are actually ready to inject. And now, once you remove this white cap, you’ll see a green safety guard. This is where the needle is tucked away inside. And that’s the end you want to place against your skin.

        MARY: I don’t see the needle.

        LORIE: Exactly!

        MARY: Oh.

        LORIE: The SureClick is designed so you don’t have to see the needle. So, keep in mind, once you remove this white cap, you want to inject within 5 minutes to prevent the medicine from drying out. Now there’s one more part I want you to look at. See this window? That clear liquid is the ENBREL medicine. Always make sure that it’s clear, has no clumps or flakes floating in it. If the medicine inside looks cloudy, discolored or your SureClick has expired, don’t use it. You’ll want to contact your doctor right away. Or you can call 1-888-4ENBREL to get a replacement. So, where’s your ENBREL SureClick now?

        MARY: In my fridge. I put it in there right after I got it.

        LORIE: Perfect. Let’s go get one of the SureClicks out of the box.

        MARY: Okay, follow me. I need to warn you, my fridge is a bit messy. Don’t judge me.

        LORIE: Don’t worry! You should see my fridge!

        LORIE: I see you keep your SureClick on the top shelf. That’s perfect, you want to keep it out of reach of children.

        MARY: Got it.

        LORIE: Couple quick things to keep in mind. Never freeze it or store it in extreme heat or cold. Don’t shake it. And always store it in its original carton, like you have. That protects it from light damage. And remember, leave your unused medication in the refrigerator. Now take your SureClick out of the fridge, then wait. You want this to get to room temperature. Injecting at room temperature can make for a more comfortable injection. So, let it sit out for about 30 minutes. While you wait, you can stream a show. Take a walk. Just make sure it’s out of reach of small children and pets.

        MARY: Ah, I know just the place. Oh, question—I’m going on vacation soon. I’m going to be staying at a hotel for about a week, and I’m not sure if they have a refrigerator or anything. Can I travel with ENBREL?

        LORIE: Absolutely. ENBREL can actually be at room temperature for up to 30 days. So you can actually bring it with you in your carry-on, and keep taking it right on schedule.

        MARY: That’s perfect.

        LORIE: But for today, let’s just do 30 minutes.

        MARY: Okay.

        LORIE: Oh, one more thing. Once Enbrel comes to room temperature, do not put it back in the refrigerator.

        MARY: Good to know. Wow. That was a fast 30 minutes.

        LORIE: Well, first things first: let’s wash your hands thoroughly.

        MARY: I’m all set.

        LORIE: Alright, let’s go get your SureClick down.

        MARY: Okay.

        LORIE: Now, this is everything you’ll need. Cotton balls, alcohol wipes, a bandage, and a sharps container for when you’re done.

        MARY: Great.

        LORIE: So, today you’ll be injecting into your thigh.

        MARY: Okay.

        LORIE: But you can see other injection areas in your Instructions for Use.

        SUPER:

        AREAS YOU CAN INJECT: Stomach (2 inches away from belly button). Back of the upper arm (caregiver needs to give the injection on this site). Thigh. You should choose a different site each time you inject. Do not inject in the same exact spot as the previous injection. Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid injecting into areas with scars or stretch marks. You should avoid injecting directly into raised, thick, red, or scaly skin patch or lesion.

        LORIE: Now, let’s use an alcohol wipe to clean a 2-inch circle around where you’re going to inject.

        MARY: Okay.

        LORIE: And then we’ll let it dry. Okay, now hold the SureClick so you can easily see this window when you’re injecting.

        MARY: Okay.

        LORIE: And you’ll want to remove the white cap. And remember don’t remove the white cap more than 5 minutes prior to injecting to avoid the medicine drying out. So, now you’ll want to stretch your skin slightly to create a firm surface. There you go, perfect. Hold the SureClick at a
        90-degree angle on your skin. An easy way to remember these next steps is something I call “push, press, count”. Now push the green safety guard firmly against your skin—remembering 90 degrees. Now this is important: don’t touch the purple button until you’re actually ready to inject.

        MARY: I think I’m ready.

        LORIE: Okay! And remember keep pushing the SureClick against your skin. It takes about 15 seconds to get the full dose.

        MARY: Okay.

        LORIE: So, we’re going slowly to count slowly to 15, just to make sure. Okay, now press the purple button all the way down and release the button. And now count…

        MARY: One, two, three, four, five,…

        LORIE: And don’t forget to keep an eye on that window, too.

        MARY: ...twelve, thirteen, fourteen, fifteen. The window is yellow now.

        LORIE: Great! That means the injection is complete. So that’s an important reason why you always want to check that window before you remove it from the skin. If you remove the SureClick too early, you may not receive your full dose of Enbrel. So, call your doctor if you think you didn’t receive the full dose. And remember: Push. Press. Count.

        MARY: Push. Press. Count. Thanks Lorie. It was helpful having you here today.

        LORIE: Oh, that’s great! So, there’s a bandage there if you need it.

        MARY: Great.

        LORIE: And next, you’re going to want to dispose of your empty SureClick safely. There’s no medicine in it anymore, but it does have a needle, so you can’t just throw them in your household trash or recycling. You want to put the used SureClick autoinjector in an FDA-cleared sharps disposal container right away after use. Drop it in, seal it up, and make sure your kids and pets can’t get to it.

        MARY: That’s it?

        LORIE: That’s it.

        MARY: Thanks so much for coming. I’m really much more comfortable now that we went over this.

        LORIE: Of course, it’s my pleasure! And remember to refer to your Instructions for Use if you have any questions. And you can also call ENBREL Support. We’re happy to help!

        MARY: Awesome. Bye now!

        LORIE: Bye!

        COLLAPSE

      The SureClick® autoinjector allows you to take your ENBREL with the press of a button. Plus it’s designed to make a clicking noise when you start and finish your injection.

      Please note: this device is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with JIA who weigh less than 138 pounds (63 kg).

      For more information on the SureClick® autoinjector

      Download The Guide
      COLLAPSE

    • Prefilled Syringe

      PREFILLED SYRINGE

      Prefilled syringes are manually injected, which means you control the rate of injection. Each one contains a single dose.

      Please note: the 25-mg syringe is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with JIA who weigh less than 68 pounds (31 kg).

      Please note: the 50-mg syringe is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with JIA who weigh less than 138 pounds (63 kg).

      For more information on the Prefilled syringe

      Download The Guide
      COLLAPSE

      • READ VIDEO TRANSCRIPT

        How it Works

        Indication
        Enbrel® (etanercept) is indicated for the treatment for patients with moderately to severely active rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, moderate to severe plaque psoriasis in adults and children 4 years and older, and moderately to severely active polyarticular juvenile idiopathic arthritis.

        VO:

        LISA (to camera): Hi, I’m Lisa. I’m an ENBREL Nurse Partner™.

        MARY (to camera): And I’m Mary. I’m just getting started on ENBREL. So I called up ENBREL® SupportPlus and asked for a Nurse Partner to come over and help me with my first injection. And here she is.

        LISA: Glad to be here.

        MARY (to camera): Believe me, I’m happy to have you.

        LISA (to camera): So today, I’ll be showing Mary—and everyone watching this video—how to use the ENBREL prefilled syringe. Think of this as supplemental support to the training you received at your doctor’s office. Now before we get started, there’s a few things to go over.

        LISA: When you received your ENBREL, it should have come with this: it’s called an Instructions For Use.

        MARY: Got it right here.

        LISA: Perfect.

        MARY: A nurse at my doctor’s office took me through it when she trained me. And I read it again before you showed up.

        LISA: Don’t lose it. It contains everything you need to know about injecting with the prefilled syringe. Review it before each injection. It can also answer a lot of questions you may have later.

        MARY: I’ll put it somewhere safe.

        LISA: Great. Ready?

        MARY: Ready.

        LISA (to camera): Ready?

        LISA: I think they’re ready.

        MARY: Let’s do it.

        LISA (to camera): So, right off the bat, the prefilled syringe comes in 2 doses, 50 milligrams and 25 milligrams. Which dose you’ll use depends on what your doctor prescribed. Which do you have, Mary?

        MARY: I have 50 milligrams.

        LISA (to camera): Mary only needs one syringe today, but some people at home may need to use 2 25-milligram syringes. The injection steps are the same. Your doctor will let you know whether to take them both on the same day or on 2 different days in the same week.

        MARY (to camera): Make sure to follow your doctor’s instruction.

        LISA (to camera): That’s right. So, where’s your ENBREL now?

        MARY: In my fridge. I put it in there right after I got it.

        LISA: Great. Let’s grab one.

        MARY: I keep it on the top shelf, in the back, behind the leftovers I never eat.

        LISA: Best place for it. You want to make sure kids can’t get to it. Couple of other things to keep in mind: never freeze ENBREL or store it in extreme heat or cold. Don’t shake it, it’s already mixed. And always keep it in its original carton. This protects the medicine from light or physical damage.

        MARY: Oh, I didn’t know that.

        LISA: Take one out. But leave the rest in there until you’re ready to use them. Now put it somewhere high up, like over there. Anywhere kids and pets can’t get to it.

        MARY: I take it we’re not injecting just yet.

        LISA (to camera): Nope. It’s best to let your ENBREL slowly warm up to room temperature before you use it. It can make the injection more comfortable.

        MARY: How long does that take?

        LISA: Give it about 30 minutes.

        MARY: I have a question: so the instructions say I should keep the medicine refrigerated until I’m ready to use it. But what if I go on vacation? I can’t lug the refrigerator along with me. So, what do I do then?

        LISA: Take your ENBREL with you, of course. Once ENBREL warms up to room temperature, it can stay like that for up to 30 days. Just pack it in your carry-on and go do you. You want to keep taking your ENBREL on schedule.

        MARY (to camera): Well, that solves that problem.

        LISA (to camera): But remember, once ENBREL has reached room temperature, don’t put it back in the fridge.

        MARY: Got it. Looks like we have another 25 minutes to go. How about we just fast forward ahead?

        LISA: Let’s. OK, first things first: wash your hands. Then get your ENBREL down.

        MARY: On it.

        LISA (to camera): There are three things you need to always check before injecting. Make sure your medicine hasn’t expired. You’ll find the expiration date on the syringe, there.

        MARY: Still good.

        LISA: Make sure the needle cover is securely attached.

        MARY: On tight.

        LISA: Now, take a look at the liquid inside. It should be clear. Sometimes you might see some tiny white particles. That’s OK. If the liquid ever looks cloudy, discolored, or has large particles—don’t use it. Call your doctor, or you can call 1-888-4ENBREL for a replacement. And if you’re ever unsure, give ENBREL® SupportPlus a call. They will be happy to help you. There are a couple of other things you’ll need handy before you start. Alcohol wipes, some cotton balls, a bandage, and a sharps container.

        MARY: Got them all right here.

        LISA: Now let’s check the syringe for bubbles. Pick it up and hold it with the needle pointing down. If there are any bubbles, give the syringe a gentle flick or two to get them to rise to the top.

        MARY: And up they go.

        LISA: Then, turn the syringe around until you see 2 purple lines. As long as the liquid falls between them, the syringe has the right amount of ENBREL in it.

        MARY: Right where it should be.

        LISA: There are 3 different places where you can inject. And you should use a different spot each time. You can do the front of either thigh, in the middle; your stomach, as long as you stay two inches away from your belly button; or the back of your upper arms, but someone else should do that injection for you.

        SUPER: AREAS YOU CAN INJECT: Stomach (2 inches away from belly button). Back of the upper arm (caregiver needs to give the injection on this site). Thigh (front of either thigh, in the middle). You should choose a different site each time you inject. Do not inject in the same exact spot as the previous injection. Do not inject into areas where the skin is tender, bruised, red, or hard. Avoid injecting into areas with scars or stretch marks. If you have psoriasis, you should avoid injecting directly into raised, thick, red, or scaly skin patches or lesions.

        LISA (to camera): I know this is a lot to remember! Refer back to your Instructions for Use if you have any questions. Everything is listed in there. Or you can call your doctor. Where would you like to do it today?

        MARY: My thigh.

        LISA: To start, use an alcohol wipe to clean the injection area. Now let it dry. And don’t touch that spot again until you’re ready to go.

        MARY: OK. Letting it dry.

        LISA: Once it’s dry, grab the syringe by the barrel with one hand and pull the needle cover straight off with the other. Be careful not to touch or bump the plunger. You don’t want to accidentally lose any medicine.

        MARY: OK. I’ll be careful.

        LISA: Right before you inject, check for bubbles again. But this time, hold the needle pointing up. If there are bubbles, like before, give it a very gentle tap ’til they rise to the top. To get that air out, slowly push the plunger up until it’s gone.

        MARY: Just like in the movies.

        LISA: So now we’re ready to go. You’ll want to pinch your skin gently. Just like that. At a 45-degree angle, quickly and firmly insert the needle into the skin. Once it’s all the way in, stop pinching your skin. With your free hand, hold the base of the syringe to keep it steady. Slowly push the plunger all the way down. Yup, just like that. Take your time, there’s no rush.

        MARY: OK, it’s all the way down.

        LISA: When the syringe is empty, remove it at the same angle and put it right in that sharps container. There’s no medicine in the syringe anymore, but there’s still a needle. You don’t want that in your trash or recycling. And if you need to, use a cotton ball to dab the injection spot.

        MARY: I’ll use a bandage too,... just in case. New outfit.

        LISA: If for any reason... .you think you didn’t receive your full dose, call your doctor right away.

        MARY: So, that’s it?

        LISA: That’s it.

        MARY: Thank you so much, Lisa. This was super helpful. Hopefully everyone watching feels the same way.

        COLLAPSE

      Prefilled syringes are manually injected, which means you control the rate of injection. Each one contains a single dose.

      Please note: the 25-mg syringe is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with JIA who weigh less than 68 pounds (31 kg).

      Please note: the 50-mg syringe is not for use in children (ages 4-17 years) with chronic moderate to severe plaque psoriasis or children with JIA who weigh less than 138 pounds (63 kg).

      For more information on the Prefilled syringe

      Download The Guide
      COLLAPSE

    • Single-Dose Vial

      SINGLE-DOSE VIAL

      The single-dose vial is the only option available for children (4-17 years) width chronic moderate to severe plaque psoriasis and children with JIA who weigh less than 68 pounds (31 kg).

      Please note: syringes and needles are not supplied with the single-dose vial, though they are required for injection. They may require a separate prescription from your doctor. We recommend the following:

      • Syringes: 1-mL Luer lock
      • Withdrawal needles: 22-guage, sterile needles with Luer-lock connection. Length: 1.5 inches
      • Injection needles: 27-guage, sterile needles with Luer-lock connection. Length: .5 inch

      Two vials may be required to administer the total prescribed dose. Use the same syringe for each vial. The vial does not contain preservatives; therefore, discard unused portions.

      For more information on the single-dose vial

      Download The Guide
      COLLAPSE

      • READ VIDEO TRANSCRIPT

        How it Works

        Indication
        Enbrel® (etanercept) is indicated for the treatment for patients with moderately to severely active rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, moderate to severe plaque psoriasis in adults and children 4 years and older, and moderately to severely active polyarticular juvenile idiopathic arthritis.

        VO:

        MARY: Coming!

        LORIE: Mary?

        MARY: Hi!

        LORIE: Hi, I’m Lorie, your ENBREL Nurse Partner.

        MARY: Hi, Lorie. Come on in! Thanks for coming over.

        LORIE: Absolutely, my pleasure.

        LORIE: So, as you know, I’m here to help you as you get started with the ENBREL single-dose vial. Think of today as a demonstration that can help supplement the training that you received in your physician’s office. Now, I’ll go over things in detail. But before I do, your single-dose vial came with an Instructions for Use.

        MARY: Yup, I have one. I reviewed it with the nurse when we received training in the office, and I read it all the way through just before you came over. I’m really glad you’re here, because this is the first time I’m injecting myself at home.

        LORIE: Of course. And you should always read the instructions for use before injecting and refer to it if you have any questions.

        MARY: Perfect.

        LORIE: Alright, are you ready to get started?

        MARY: Ready.

        LORIE: Now, before you do the actual injection, I want to show you some features of the single-dose vial. Let’s start with the vials.

        MARY: Great.

        LORIE: Each one holds .5 milliliters of medicine. If your prescribed dose is .5 milliliters or less, you’ll need one vial. If your prescribed dose is more than .5 milliliters, you’ll need 2 vials.

        MARY: My prescription is for 1 milliliter a week, so I’ll need 2 vials.

        LORIE: Exactly. You’ll also need one short needle for injecting, one long needle to withdraw the medicine from the vials, and a 1-millimeter syringe. You can use the same syringe to withdraw the medicine from each vial. But only use the syringe one time when it comes to your injection. There are three things you should always check before you begin. Make sure your vials haven’t expired, make sure the green cap is attached, and make sure the medicine inside doesn’t look lumpy, discolored, or cloudy. Now look inside, see how the medicine looks?

        MARY: It’s clear and colorless. I do see some small white particles though.

        LORIE: And you may see tiny white particles sometimes, but not always. Just make sure it never looks lumpy, discolored, or cloudy–if it does, don’t use it. Contact your doctor, or you can call 1-888-4ENBREL to get a replacement.

        MARY: Noted.

        LORIE: So, where’s your ENBREL single-dose vial now?

        MARY: In my fridge. I put it in there right after I got it.

        LORIE: Perfect. Let’s go get your single-dose vials out of the fridge now.

        MARY: Okay. Follow me. I need to warn you—my fridge is a bit messy. Don’t judge.

        LORIE: No worries! You should see my fridge! I see you keep your single-dose vials on the top shelf. That’s perfect. You want to keep it out of reach of children. Couple quick things to keep in mind, never freeze it or store it in extreme heat or cold. Don’t shake it. And always store it in its original carton, like you have. That protects it from light damage. And remember to keep your unused vials in the refrigerator. Now take your single-dose vials out of the fridge. Then wait. You want this to get to room temperature. Injecting at room temperature can make for a more comfortable injection. So, let it sit out for about 30 minutes. You can take a walk. Stream a show. Just make sure it’s out of reach of children and pets.

        MARY: Ah, I know just the place.

        LORIE: Perfect.

        MARY: Oh, question, I’m going to be going out of town. And I don’t know if the hotel will have a refrigerator or anything. Can I travel with ENBREL?

        LORIE: Absolutely. ENBREL can actually be at room temperature for up to 30 days. So you can actually bring it with you in your carry-on, and keep taking it right on schedule.

        MARY: That’s perfect.

        LORIE: But for today, let’s just do 30 minutes.

        MARY: Okay.

        LORIE: Oh, one more thing. Once ENBREL comes to room temperature, do not put it back in the refrigerator.

        MARY: Got it. Wow, that was a fast 30 minutes.

        LORIE: Well, first things first, let’s wash your hands thoroughly.

        MARY: Well, I’m all set.

        LORIE: Alright, let’s get your vials down.

        MARY: Okay.

        LORIE: This is what you’ll need. A 1-milliliter syringe, the long needle for withdrawal, the short needle for injecting, alcohol wipes, cotton balls, bandage, and of course the sharps container for disposal. The first thing you’re going to do is pop off the green caps. Take two alcohol wipes to wipe down each of the gray stoppers here. Twist the long needle onto the syringe. Remove the needle cover. Now, pull back the plunger to the
        0.5-milliliter mark. Okay, so hold the vial firmly and insert the needle into the gray stopper. Just like that. Now this is important, keep the needle above the medicine for now. Slowly push 0.5 milliliters of air into the vial. Okay, tilt the vial at a 45-degree angle—like this. And now keep the needle tip below the medicine to avoid pulling air into the syringe. Then slowly pull back the plunger and fill the syringe. And make sure you got all the medicine out. Now, let’s gently tap the syringe, just like you see in movies. This gets the air bubbles and air pockets to the top. After the air bubbles rise to the top, carefully push the plunger until they’re pushed out. A small amount of tiny air bubbles are okay. Even though some medication may be spilled out make sure you have enough for your prescribed dose. Okay, now let’s do the other vial. So, you want to insert the same needle in. And then tilt the vial at a 45-degree angle. Perfect. Then slowly pull back the plunger and fill the syringe. And make sure you got all the medicine out. Then tap the syringe again to have the air bubbles and air pockets rise to the top. Push the plunger to get rid of the air. Then push the plunger to your prescribed dose. For you that’s 1 milliliter. Let’s recap the needle for now, using this nifty technique called the 1-handed scoop method. Slide the needle into the cap and scoop upwards. Just like that! Now we can prepare the syringe to inject your medicine. So, let’s remove the long needle by twisting it off and replace it with the short needle by twisting it on. We don’t need the long needle anymore, so throw it away in your FDA-cleared sharps disposal container. So today you’ll be injecting into your thigh. But you can see other injection areas in your Instructions for Use. Let’s use another alcohol wipe to clean the injection area. That’s great. Now let it dry, and don’t touch that area again until you’re ready to inject.

        MARY: Got it.

        LORIE: Now pinch your skin gently. Perfect, just like that. Now at a 45-degree angle, firmly and quickly insert the needle into the skin. Then slowly push the plunger down, all the way down. Yup, just like that.

        MARY: Okay, all the way down.

        LORIE: Perfect. When the syringe is empty, remove it from your skin. You’ll want to put the syringe and the needle in a sharps container.

        MARY: Okay.

        LORIE: There’s no medicine in it anymore, but there is still a needle. So you can’t just throw it away in your household trash or recycling. Great, now use a cotton ball and press lightly on the injection site.

        MARY: I’ll put a bandage on as well.

        LORIE: One more thing, if you think you didn’t receive your full dose, call your doctor.

        MARY: Thanks Lorie. It was helpful having you here today.

        LORIE: I’m so glad. Last thing we’re going to do is dispose of your used single-dose vials safely. Even if there is some medicine in it, you can’t use it a second time. Drop it in, seal it up and just make sure your kids and pets can’t get to it

        MARY: That’s it?

        LORIE: That’s it.

        MARY: Thanks so much for coming. I’m really much more comfortable now that we went over this.

        LORIE: Of course, it’s my pleasure. And remember to refer to your Instructions for Use if you have any questions. And you can also call ENBREL Support. We’re happy to help!

        MARY: Awesome. Bye now!

        LORIE: Bye!

        COLLAPSE

      The single-dose vial is the only option available for children (4-17 years) width chronic moderate to severe plaque psoriasis and children with JIA who weigh less than 68 pounds (31 kg).

      Please note: syringes and needles are not supplied with the single-dose vial, though they are required for injection. They may require a separate prescription from your doctor. We recommend the following:

      • Syringes: 1-mL Luer lock
      • Withdrawal needles: 22-guage, sterile needles with Luer-lock connection. Length: 1.5 inches
      • Injection needles: 27-guage, sterile needles with Luer-lock connection. Length: .5 inch

      Two vials may be required to administer the total prescribed dose. Use the same syringe for each vial. The vial does not contain preservatives; therefore, discard unused portions.

      For more information on the single-dose vial

      Download The Guide
      COLLAPSE

  • Travel and storage

    TIPS FOR TRAVELING WITH YOUR ENBREL MEDICATION

    When traveling with your ENBREL it’s important not to miss your injections,
    so please keep the following in mind:

    ENBREL can be kept at room temperature, (between 68°F to 77°F) for up for 30 days. It cannot be put back in the fridge once it reaches room temperature, so keep this in mind when making travel plans.

    If you haven't received a travel kit already,
    you can request one by speaking to an Amgen Nurse Partner at 1-888-4ENBREL
    (1-888-436-2735). While on the phone, they can also tell you more about storage and how to travel with ENBREL.

    • What to bring in a travel bag

      How to travel with your ENBREL® medication
      • Your ENBREL medication
      • ENBREL syringes or injectors in their original containers
      • A sharps container for easy needle disposal
      • ENBREL Travel Kit
      • A copy of your prescription

    • How to store ENBREL on a trip

      How to store ENBREL® when traveling
      • ENBREL can be stored at room temperature (between 68°F to 77°F) for up to 30 days
        • If you’re traveling somewhere with extreme heat or cold, or if you will be traveling for more than 30 days, please contact us or your specialty pharmacy before your trip for guidance on refrigeration while traveling
      • Pack ENBREL in carry-on baggage in a
        zip-top bag
      • Refrain from shaking your ENBREL
      • Always keep your ENBREL and other medicines out of the reach of children
      • You can request an ENBREL Travel Kit to help you

    • How to navigate security checkpoints

      How to navigate TSA and security checkpoints with ENBREL®
      • At the start of the screening process, tell the TSA officer that you have medically required liquids in a zip-top bag
      • Your ENBREL medication may be subject to additional screening, which may include opening the medication container
      • Medications in liquid form in excess of 3.4 ounces are allowed in carry-on baggage at reasonable quantities
      • Medication is usually screened by X-ray. X-ray screeners at TSA checkpoints should not affect your ENBREL. However, you may ask beforehand for a hand inspection
      • Be sure to review the TSA Travel Guidelines for the most current regulations

  • Specialty pharmacy

    WORKING WITH A
    SPECIALTY PHARMACY

    Specialty pharmacies help people get medications that require special storage and/or handing—like ENBREL. As a result, most patients have their ENBREL delivered to their door by a specialty pharmacy. The video below covers how that process works and what you need to do to help you receive your ENBREL quickly and smoothly.

    • READ VIDEO TRANSCRIPT

      Working with a specialty pharmacy

      Indication
      Enbrel® (etanercept) is indicated for the treatment for patients with moderately to severely active rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, moderate to severe plaque psoriasis in adults and children 4 years and older, and moderately to severely active polyarticular juvenile idiopathic arthritis.

      VO:

      Talent 1: You might be wondering, what happens after your doctor prescribes ENBREL? Getting ENBREL can be different for everyone, but for most patients it begins with your doctor sending a prescription to a specialty pharmacy. The specialty pharmacy will work with your doctor and insurance provider to process your prescription. So what is the specialty pharmacy and why will they be calling you? Specialty pharmacies handle specialty medication, such as those that are injected and need to be refrigerated. ENBREL is one of these medications. You will receive a call from the pharmacist to arrange for payment for your prescription and talk about your ENBREL delivery. The pharmacist can also answer questions and counsel you on how to store and administer ENBREL as well as potential side effects, and any drug interactions with other medications you may be taking. If you’re like a lot of people you might not answer phone calls from unknown numbers, but it is important to remember that your specialty pharmacy may be trying to reach you about your ENBREL prescription. This is why it is necessary to look out for a phone call coming from an unknown caller from the time your doctor prescribes ENBREL in case it is your specialty pharmacy. You may also find it helpful to save the name and number of your specialty pharmacy so you know when they are calling. And don’t forget if you have an ENBREL co-pay card remember to have it handy and be ready to provide the number on the card to the pharmacist. The pharmacist will talk to you about scheduling the delivery of your ENBREL prescription and a time and place that works best for you. It’s important that you or someone you trust is available to receive your ENBREL prescription because it needs to be refrigerated. Don’t forget you can ask your pharmacist to help answer questions you have about getting your ENBREL prescription delivered to you. If you still have additional questions about injecting ENBREL or establishing a routine, you can call ENBREL Support to enroll in the ENBREL Nurse Partner program and connect with an ENBREL Nurse Partner. Remember to enroll in ENBREL Support to take advantage of additional support services and resources today. You can simply call, visit the website, or scan the QR code to enroll.

      COLLAPSE
    COLLAPSE

  • How support from ENBREL can help

    Amgen® SupportPlus for ENBREL®Amgen® SupportPlus for ENBREL®

    HOW SUPPORT FROM ENBREL CAN HELP

    Amgen SupportPlus is a personalized patient support program designed for patients like you who take certain Amgen medications, including ENBREL. It offers a variety of resources including financial support information, supplemental injection support, and tools to help you stay on track with your medication.
    COLLAPSE
FAQs about ENBREL®FAQs about ENBREL®

More questions?
Check out our FAQs.

If you don’t see your question answered in the page above, chances are we’ve got it covered on our Frequently Asked Questions page.

Prescription Enbrel® (etanercept) is taken (given) by injection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections. Serious infections have happened in patients taking ENBREL. These infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some patients have died from these infections. Your healthcare provider should test you for TB before you take ENBREL and monitor you closely for TB before, during, and after ENBREL treatment, even if you have tested negative for TB.

There have been some cases of unusual cancers, some resulting in death, reported in children and teenage patients who started using tumor necrosis factor (TNF) blockers before 18 years of age. Also, for children, teenagers, and adults taking TNF blockers, including ENBREL, the chances of getting lymphoma or other cancers may increase. Patients with RA may be more likely to get lymphoma.

Before starting ENBREL, tell your healthcare provider if you:

  • Have any existing medical conditions
  • Are taking any medicines, including herbals
  • Think you have, are being treated for, have signs of, or are prone to infection. You should not start taking ENBREL if you have any kind of infection, unless your healthcare provider says it is okay
  • Have any open cuts or sores
  • Have diabetes, HIV, or a weak immune system
  • Have TB or have been in close contact with someone who has had TB
  • Were born in, lived in, or traveled to countries where there is more risk for getting TB. Ask your healthcare provider if you are not sure
  • Live, have lived in, or traveled to certain parts of the country (such as, the Ohio and Mississippi River valleys, or the Southwest) where there is a greater risk for certain kinds of fungal infections, such as histoplasmosis. These infections may develop or become more severe if you take ENBREL. If you don’t know if these infections are common in the areas you’ve been to, ask your healthcare provider
  • Have or have had hepatitis B
  • Have or have had heart failure
  • Develop symptoms such as persistent fever, bruising, bleeding, or paleness while taking ENBREL
  • Use the medicine Kineret (anakinra), Orencia (abatacept), or Cytoxan (cyclophosphamide)
  • Are taking anti-diabetic medicines
  • Have, have had, or develop a serious nervous disorder, seizures, any numbness or tingling, or a disease that affects your nervous system such as multiple sclerosis or Guillain-Barré syndrome
  • Are scheduled to have surgery
  • Have recently received or are scheduled for any vaccines. All vaccines should be brought up-to-date before starting ENBREL. Patients taking ENBREL should not receive live vaccines
  • Are allergic to rubber or latex
  • Are pregnant, planning to become pregnant, or breastfeeding
  • Have been around someone with chicken pox

What are the possible side effects of ENBREL?

ENBREL can cause serious side effects including: New infections or worsening of infections you already have; hepatitis B can become active if you already have had it; nervous system problems, such as multiple sclerosis, seizures, or inflammation of the nerves of the eyes; blood problems (some fatal); new or worsening heart failure; new or worsening psoriasis; allergic reactions; autoimmune reactions, including a lupus-like syndrome and autoimmune hepatitis.

Common side effects include: Injection site reactions and upper respiratory infections (sinus infections).

In general, side effects in children were similar in frequency and type as those seen in adult patients. The types of infections reported were generally mild and similar to those usually seen in children.

These are not all the side effects with ENBREL. Tell your healthcare provider about any side effect that bothers you or does not go away.

If you have any questions about this information, be sure to discuss them with your healthcare provider. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see Prescribing Information and Medication Guide.

INDICATIONS

Moderate to Severe Rheumatoid Arthritis (RA)

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBREL can be taken with methotrexate or used alone.

Psoriatic Arthritis

ENBREL is indicated for reducing signs and symptoms, keeping joint damage from getting worse, and improving physical function in patients with psoriatic arthritis. ENBREL can be used with or without methotrexate.

Moderate to Severe Plaque Psoriasis

ENBREL is indicated for chronic moderate to severe plaque psoriasis (PsO) in children 4 years and older and adults who may benefit from taking injections or pills (systemic therapy) or phototherapy (ultraviolet light).

Ankylosing Spondylitis (AS)

ENBREL is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

Moderately to Severely Active Polyarticular Juvenile Idiopathic Arthritis (JIA)

ENBREL is indicated for reducing signs and symptoms of moderately to severely active polyarticular juvenile idiopathic arthritis (JIA) in children ages 2 years and older.

Prescription Enbrel® (etanercept) is taken (given) by injection.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENBREL?

ENBREL is a medicine that affects your immune system. ENBREL can lower the ability of your immune system to fight infections.